بانک مقالات

ترکیب مهندسی متابولیک و بهینه سازی فرایند برای بهبود تولید و دفع اسید های چرب

Combining metabolic engineering and process optimization to improve production and secretion of fatty acids

سال انتشار : 2016

تعداد صفحه : 9

کلیدواژه ها:  Synthetic biology, Lipid secretion, Microbial oil, Biodiesel, Yarrowia lipolytica, Oleaginous yeasts, Free fatty acids, Oleochemicals, Microbial biotechnology, Single cell oil, Metabolic engineering, Industrial biotechnology

   دانلود    سفارش ترجمه

ABSTRACT

Microbial oils are sustainable alternatives to petroleum for the production of chemicals and fuels. Oleaginous yeasts are promising source of oils and Yarrowia lipolytica is the most studied and engineered one. Nonetheless the commercial production of biolipids is so far limited to high value products due to the elevated production and extraction costs. In order to contribute to overcoming these limitations we exploited the possibility of secreting lipids to the culture broth, uncoupling production and biomass formation and facilitating the extraction. We therefore considered two synthetic approaches, Strategy I where fatty acids are produced by enhancing the flux through neutral lipid formation, as typically occurs in eukaryotic systems and Strategy II where the bacterial system to produce free fatty acids is mimicked. The engineered strains, in a coupled fermentation and extraction process using alkanes, secreted the highest titer of lipids described so far, with a content of 120% of DCW.

زبان فایل

مجلات و ژورنال های بین المللی

Elsevier

ترجمه

نوع فایل

رایگان

سال انتشار

2016

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